HIV-1 Infection in Persistently HIV-1-Seronegative Individuals: More Reasons for HIV RNA Screening
نویسندگان
چکیده
منابع مشابه
Functional HIV-1 specific IgA antibodies in HIV-1 exposed, persistently IgG seronegative female sex workers.
Although HIV-specific cellular immune responses are found in a number of HIV highly-exposed, persistently seronegative (HEPS) cohorts, late seroconversion can occur despite pre-existing cytotoxic T lymphocytes (CTL), suggesting that a protective HIV vaccine may need to induce a broader range of HIV-specific immune responses. Low levels of HIV-specific IgA have been found in the genital tract an...
متن کاملتوسعه روش NASBA-ELISA برای تشخیص HIV-1 RNA
چکید ه سابقه و هدف با شروع عفونت HIV-1 ، اولین مارکری که در خون آشکار می‌شود، RNA ویروسی می‌باشد. از میان روش‌های موجود که شناسایی RNA را هدف قرار می‌دهند؛ متداول‌ترین روش‌ها NASBA و RT-PCR هستند. NASBA مزیت‌های متعددی نسبت به RT-PCR ارایه می‌کند. در این پژوهش، واکنش NASBA در ترکیب با روش آشکارسازی آسان و حساس الایزا، برای تشخیص و آشکارسازی HIV-1 RNA مورد استفاده قرار گرفت. مواد و روش‌ه...
متن کاملEvaluation of clinical course and laboratory findings in HIV/HTLV-1 co-infection compare with HIV mono infection
Background: In the last 10 years, co-infection of human immunodeficiency virus/human T-cell leukemia virus-1 (HIV/HTLV-1) has emerged as a worldwide health problem. These viruses has the same route to infect human but different effects on CD4 positive T-cells. There was controversial results about the influence of co-infection HIV/HTLV-1 pathogenesis. This study compared clinical course and lab...
متن کاملTLR activation pathways in HIV-1-exposed seronegative individuals.
TLRs trigger innate immunity that recognizes conserved motifs of invading pathogens, resulting in cellular activation and release of inflammatory factors. The influence of TLR activation on resistance to HIV-1 infection has not been investigated in HIV-1 exposed seronegative (ESN) individuals. PBMCs isolated from heterosexually ESN individuals were stimulated with agonists specific for TLR3 (po...
متن کاملMucosal and plasma IgA from HIV-exposed seronegative individuals neutralize a primary HIV-1 isolate.
OBJECTIVE To characterize functional properties of HIV-specific IgA in samples representing both systemic and mucosal compartments of HIV-1 highly exposed persistently seronegative (HEPS) individuals. METHODS IgA was purified from plasma and mucosal samples from HEPS individuals and tested for the ability to neutralize infection of peripheral blood mononuclear cells (PBMC) by a non-syncytium ...
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ژورنال
عنوان ژورنال: Clinical Infectious Diseases
سال: 2008
ISSN: 1058-4838,1537-6591
DOI: 10.1086/527569